Changing Escherichia coli‘s genetic code may enable the recoded bacterium to be grown in large vats for drug production, without the risk of a viral infection upending the process
4 August 2022
Some viruses can infect and kill a recoded Escherichia coli bacterium that was supposedly resistant to all viral infections, but further changes have made the bacterium much more virus-resistant.
Many chemicals and drugs, such as insulin, are produced by growing genetically engineered E. coli in large vats, but bacteria-infecting viruses called bacteriophages can wreak havoc. “If a single bacteriophage gets into these …